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KMID : 0525720150200010046
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Journal of Chitin and Chitosan
2015 Volume.20 No. 1 p.46 ~ p.50
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Antibacterial Effects of Glycol Chitosan-Eicosapentaenoic Acid Nanoparticles Containing Cinnamon Oil
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Kim Jin
Lee Chang-Moon
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Abstract
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In this study, cinnamon oil (CIO) was loaded into glycol chitosan-eicosapentaenoic acid nanoparticles (GC-EPA NPs) and their antibacterial effects were evaluated against Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis). The GC-EPA conjugate was synthesized through amide bonding and the conjugate could self-assemble into core-shell structure in aqueous solution. The GC-EPA NPs containing CIO (GC-EPA NPs-CIO) were prepared by incorporating CIO into the core of NPs via hydrophobic interaction. The GC-EPA NPs-CIO inhibited cell growth over 95% at 0.3% (w/w) concentration against S. aureus and S. epidermidis. Therefore, it is expected that the GC-EPA NPs-CIO may have a potential for widening the use of CIO in various industrial fields including medicines and cosmetics.
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KEYWORD
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Antibacterial effect, Cinnamon oil, Eicosapentaenoic acid, Essential oil, Glycol chitosan
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